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Cancer Metastasis Rev 38(12):205222 Rajeshkumar NV, Yabuuchi S, Pai SG et al (2017) Treatment of pancreatic cancer patient-derived xenograft panel with metabolic inhibitors reveals efficacy of phenformin

Glutathione steps in to neutralize these ROS, reducing the damage and aiding in cell repair

Primary glutamatergic deficit, likely originating from aberrant neuron-glia interactions, leads to an early GSH excess via diversion of GSH-glutamate metabolic pathways