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292 In HD, the GABAergic neurons in the striatum and cortex are the most affected, contributing to clinical hallmarks such as chorea, cognitive impairment and nonmotor symptoms

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Hemodynamic shear stress characteristic of atherosclerosis-resistant regions promotes glycocalyx formation in cultured endothelial cells

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A switch from white to brown fat increases energy expenditure in cancer-associated cachexia

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Moreover, alisol A downregulates the expression of MMP-2/9 to suppress cell metastasis by inhibiting the activities of PI3K/AKT/mTOR and NF-B [223]

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