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S-glutathionylation involves the covalent attachment of glutathione (GSH) to protein thiols, forming mixed disulfide bonds that protect key enzymatic sites and maintain redox homeostasis

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Itaconate, a mitochondria-derived immunometabolite, is significantly downregulated in patients with active SLE, and the loss of its antioxidant protection may contribute to disease activity [62]

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This stability has practical implications for research design, as it opens the door to oral administration routes in experimental models where most peptides would require injection