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Glial cells lining the BBB have an active role in the efflux process by taking up glutamate and releasing it in a close vicinity to the endothelium and accelerating its efflux to the blood

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Acute endotoxemia and impaired endothelium in a rodent model, has been shown MPO accumulated in and around vascular endothelial cells after leukocyte degranulation in a dependent relaxant response, to which MPO-deficient mice were resistant [120]

The formation of ice crystals can physically damage the delicate protein structure of a peptide, a process called denaturation

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