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What the Evidence Shows Its more useful to tier the evidence by study type than to cite a raw publication count, because the count includes everything from large human cohorts down to fruit fly experiments

10.1046/j.1537-2995.1981.21281178160.x 33 DelobelJ.PrudentM.RubinO.CrettazD.TissotJ

For example, oxidative or electrophilic modification of specific cysteine residues (i.e., C151) on KEAP1 causes a conformational change in the KEAP1-CUL3-RBX1-NRF2 complex that prevents NRF2 ubiquitylation and degradation (912)