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AD: Alzheimers disease ALS: amyotrophic lateral sclerosis AMPK: adenosine monophosphate-activated protein kinase A: amyloid-beta BDNF: brain-derived neurotrophic factor CREB: cAMP-response element binding protein EGCG: epigallocatechin gallate ER: endoplasmic reticulum HD: Huntingtons disease IL-1: interleukin-1 mHTT: self-propagating, amyloidogenic mutant huntingtin MS: multiple sclerosis NLRP3: nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 NMDA: N -methyl-D-aspartate Nrf2: nuclear factor erythroid 2-related factor 2 PD: Parkinsons disease PINK1: PTEN-induced kinase 1 PLGA: poly (lactic-co-glycolic acid) RCTs: randomized clinical trials ROS: reactive oxygen species SIRT1: silent information regulator sirtuin 1 SOD: superoxide dismutase TDP-43: transactive response DNA binding protein 43 TNF-: tumor necrosis factor-alpha UPR: unfolded protein response All authors thank the Graphic Era (Deemed to be University), for supporting

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Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study