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GA acquired the funding

As expected, serum ALT, AST, IL-1 and IL-1 concentrations were strongly reduced in GSDME WT mice by MeCbl, while GSDME C180A or GSDME D270A mice were resistant to liver injury and inflammatory response from BDL model (Fig

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Subjects were instructed to maintain their routine food intake and physical activity throughout the course of the study

Results: ACNs exert protective effects on MSDs by targeting multiple key signaling pathways, including mitogen-activated protein kinase (MAPK), nuclear factor-kappaB (NF-B), Wingless-related integration site (Wnt)/-catenin, phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt), adenosyl monophosphate-dependent protein kinase (AMPK), receptor activator of nuclear factor-kappa/receptor activator of nuclear factor-kappaB ligand/osteoprotegerin (RANK/RANKL/OPG) and oxidative stress signaling