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Indeed, when abnormal stimulation of OHC and IHC occurs, a reflection within the central auditory pathways, nuclei, and cortex eventually occurs

The mechanisms underlying these effects may involve protection of pancreatic beta-cells from oxidative damage 4 , repression of hepatic gluconeogenesis and lipid synthesis 5 , and regulation of muscle glycogen metabolism 6

In vivo toxicity studies of kratom The in vivo studies on kratom toxicity were performed mainly on Sprague Dawley (SD) rats to assess acute and subchronic toxicity.37, 38, 39, 40 Moreover, zebrafish embryo and brine shrimp were used as animal models to evaluate gestational toxicity and lethality, respectively