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The hallmark of the PPHN pathophysiology is increased pulmonary vascular resistance (PVR) resulting in decreased pulmonary blood flow (PBF) and hence, decreased amount of oxygenated blood returning to left side of the heart leading to hypoxia, decreased end-organ perfusion, acidosis and cyanosis (9)

Numerous studies have demonstrated its effectiveness in stimulating fibroblasts, the cells responsible for collagen synthesis

Viscosity was evaluated over a shear rate range of 0.110 0 s 1 under controlled- shear conditions

This technique is widely used in oral peptide formulations and requires molar ratios of 1:1 to 1:3 (dihexa:cyclodextrin)

Costunolide ameliorates MNNG-induced chronic atrophic gastritis through inhibiting oxidative stress and DNA damage via activation of Nrf2