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Description

mBio 12, 12:e02094-21

8-Isoprostane as a biomarker of oxidative stress in interstitial lung diseases

Liposomal encapsulation protects glutathione from enzymatic degradation in the GI tract, while S-acetylation of the cysteine thiol allows the molecule to cross cell membranes intact before intracellular esterases remove the acetyl group

When that trials early analysis showed it was unlikely to reach its stricter efficacy goal, it was shut down, leading to the early termination of this trial as well