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Animal studies have shown some teratogenic potentialis, so its not recommended during the first trimester of pregnancy

Similar to other cancers, dysregulation of cell cycle proteins is common in MM, resulting in aberrant cycles of cell division that contribute to pathogenesis

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1986), and in the case of antiandrogen drugs, the flutamide nitro group is reduced to the nitroso group (in the presence of cyclodextrins) or substituted with the phenol group (in water) (Sortino et al