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10.1016/j.jhazmat.2013.01.004 J

In zygotes formed by fertilizing normal eggs with sperm from hyperglycemic mice, insufficient TET3-mediated demethylation disrupted epigenetic reprogramming of sperm DNA, leading to hypermethylation of insulin secretion-related genes like Gck in the progenys pancreas

(1)H NMR and UHPLC/Q-Orbitrap-MS-based metabolomics combined with 16S rRNA gut microbiota analysis revealed the potential regulation mechanism of nuciferine in hyperuricemia rats