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For instance, genome-wide association studies (GWAS) enable scientists to uncover genetic variations linked to specific diseases, providing a foundation for the development of targeted therapies [258, 259]

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This process is not regulated by feed back inhibition and allows the excessive build-up of cholesterol inside the cells, leading to their transformation into foam cells that are involved in the initiation and progression of atherosclerotic lesion [Parthasarathy et al., 1999

Losing 50 pounds means losing some muscle along with the fat, especially if protein intake is inadequate during the weight loss period