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Prior to stimulation with bTNF-, the cells were incubated with vehicle (0.1% DMSO) or different inhibitors

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This review synthesises current knowledge on (i) nasal anatomy and physiological determinants of absorption and deposition, (ii) the formulation approaches for intranasal drug delivery systems, and (iii) device technologies designed to improve targeting, particularly toward the olfactory region for potential nose-to-brain delivery

These enhancements further support physical recovery and daily performance, especially for those with demanding training schedules or chronic fatigue