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The randomized, double-blind, two-arm, placebo-controlled study conducted by Arjinpathana and Asawanonda in 60 healthy medical students showed a consistent reduction in the melanin indices at all the six sites evaluated in the GSH group subjects, with a statistically significant reduction over placebo at two sites [10]

2.6 Dihydroflavonol 2.6.1 SL About 50%70% of the silymarin extract consists of the flavonolignan SL, which is extensively studied and regarded as the most active component of silymarin (Loguercio and Festi, 2011)

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Compensatory increase in ahpC gene expression and its role in protecting Burkholderia pseudomallei against reactive nitrogen intermediates