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Muscle carnitine availability plays a central role in regulating fuel metabolism in the rodent

Science 352 , aad9780 (2016)

In contrast, vascular endothelial cells, a major target of hyperglycemic damage, show no significant change in glucose transport rate when glucose concentration is elevated, resulting in intracellular hyperglycemia (Figure 35.1)

Oxidative stress exaggerates disease condition by interfering with various signaling pathways like RCAN1, CREB/ERK, Nrf2, PP2A, NFB and PI3K/Akt