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For patients with confirmed B12 deficiencywhether due to dietary restrictions, absorption issues, or conditions like pernicious anemiaB12 injections can be an effective way to quickly restore healthy levels

The ischemia and reperfusion may occur in the cardiac surgeries, where the re-oxigenation can cause serious arrhythmias with extense lesions due to the oxygen paradoxal shock, which causes ATP depletion during the ischemia, forming hypoxanthine or xanthine, that work like a substrate to the xanthine oxidase enzyme (XO), precursor form the uric acid, that acts like na antioxidant in these cases

Rapamycin exerts anti-ferroptotic effects by decreasing transferrin receptor expression, reducing cellular iron content, and activating the iron-regulated protein-1/2 (Irp1/2) system, potentially compensating for transferrin downregulation to maintain iron homeostasis (69)

similarly, diminished protein levels of SOD2 were reported in HepG2 cells treated with oleic acid (Sharma et al

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