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On the other hand, off-target inhibition of essential kinases may also be deleterious

CPP-CAND showed high selectivity and potency in inducing apoptosis in senescent cells by disrupting FOXO4-p53 foci and activating caspase pathways

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Its encoded protein, Lymphoid phosphatase (LYP), normally interacts with the T cell receptor (TCR)-modulating tyrosine kinase CSK, but this variant disrupts that interaction (69 PTPN22 knockout into human cord blood-derived nave T cells from the same donor

Furthermore, repeated administration led to notable alterations in protein corona composition, with multiple dosing promoting increased adsorption of immunoglobulins and complement proteins (Tang et al., 2022)