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The limits of passive targeting techniques are highlighted by thorough assessments of nanoparticle delivery efficiency, which have revealed that, on average, less than 1% of the injected nanoparticle dosage penetrates solid tumors [11, 12]

Furthermore, signs of gastrointestinal toxicity (nausea, vomiting, constipation, diarrhea, abdominal pain) have been observed following oral iron supplementation at different dosages in humans [55]

An overview of the glutamatergic signaling pathways described above is depicted in Figure 1

2f) as well as DNA fragmentation in HepG2 cells pretreated with exogenous H 2 O 2 (Fig

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