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Klotho efficiently suppressed NOX2/4 and ROS overproduction in hypertrophic neonatal rat cardiomyocytes and heart tissue in CKD-associated left ventricular hypertrophy mouse model 80

Onset is rapid, but the single-dose duration may be shorter than that of liposomal forms

DOI: Published: Publisher Name: Springer, Cham Print ISBN: 978-3-031-73265-2 Online ISBN: 978-3-031-73266-9 eBook Packages: Earth and Environmental ScienceEarth and Environmental Science (R0)

These special phospholipids are mainly PE containing AA or AdA, which can be converted to lipid peroxyl radicals (LPR, such as PE-AA-OO- and PE-AdA-OO-) through autoxidation, enzymatic catalysis, and the action of Fe 2 + (Kagan et al., 2017)

Half of the samples were also incubated in 4 l of 10 mM TCEP (Sigma-Aldrich) at room temperature for 30 min, to reduce oxidized thiols