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The recommendation does not constitute FDA approval

A study conducted in a mouse TNBS-induced model of colitis with CB1-, CB2- and CB1+2 double knockout mice strains showed an increase in intestinal inflammation in these groups

Reduced Side Effects : Nasal sprays bypass the gastrointestinal tract, reducing the risk of gastrointestinal irritation and improving overall tolerance

This is one of the theoretical advantages of the dual GIP/GLP-1 approach over the amylin/GLP-1 approach

In a Phase II readout released in August 2022, the pharma touted a 15.6% drop in body weight in patients taking CagriSema, versus 5.1% in comparators on semaglutide alone and 8.1% in patients treated with only cagrilintide