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Can Res 68:13691377 Liu E, Wu J, Cao W, Zhang J, Liu W, Jiang X, Zhang X (2007) Curcumin induces G2/M cell cycle arrest in a p53-dependent manner and upregulates ING4 expression in human glioma

The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation

GraphPad Prism 10.0.0 software (GraphPad Software, La Jolla, CA) was used to produce graphs and perform the statistical analyses

These observations highlight the suitability of the HepG2 model to study these events and the necessity to define cellular sensors and signaling cascades involved in the NFT-induced increase of glutathione levels

We demonstrate that high levels of mut-p53, through binding to NRF2 and impairing its canonical antioxidant activities, directly promote ROS accumulation in cancer cells