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In CRC, the reactivation or remodeling of mitochondrial metabolic pathways, particularly oxidative phosphorylation (OXPHOS) and fatty acid oxidation (FAO), is closely associated with key oncogenic processes such as the evasion of apoptosis, the maintenance of cancer stem cell properties, and the regulation of redox homeostasis [5,6,7,8]

Rather, recent evidence suggests that H 2 S exists in dynamic equilibrium with supersulfides in biological systems, leading to challenges in isolating the pure effects of H 2 S

Kidney tissue slices of Fh1 fl/fl Cre-negative control mice and Cre-positive mice in which Fh1 was lost (indicated hereafter as Fh1 / ) were subjected to the same protein extraction and cysteine labelling strategies as cells, and peptide oxidation ratios were normalised for protein abundance

Diet and Lifestyle: In conjunction with injections, dietary adjustments or oral supplementation may be considered to maintain adequate vitamin B12 levels, especially in dietary-related deficiencies

Polyphenols exert their effects by targeting multiple pathways implicated in PD, including neuroinflammation, oxidative stress (reactive oxygen species, ROS), and protein aggregation, thereby potentially protecting vulnerable neurons (12) (Figure 1)