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By integrating transcriptomic and untargeted metabolomic analyses of BM neutrophils, we revealed a pivotal role for Chac2-driven GSH metabolic reprogramming in skewing neutrophils toward the N1 phenotype, which is orchestrated by upstream IFN-I signaling

39 Zhao S, Zhang X, Zhou Y, et al

Trois axes se degagent de la litterature post-2000

Rector RS, Thyfault JP, Uptergrove GM, Morris EM, Naples SP, Borengasser SJ, Mikus CR, Laye MJ, Laughlin MH, Booth FW, Ibdah JA (2010) Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model