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Agyeman AS, Chaerkady R, Shaw PG, et al

There were no published randomized controlled trials (RCT) with Se as the only intervention agent

For instance, synthetic drugs are often derived from chemical reagents or scarce natural products dependent on non-renewable resources, whereas live bacterial drugs are predominantly sourced from readily available, biodegradable natural material [14, 15]

Previous studies have shown that inhibiting SIRT2 may enhance the stability of glucokinase (GCK) regulatory proteins, accelerate aldolase A degradation, and inhibit -cell insulin secretion via modulation of the Akt/glycogen synthase kinase-3 (GSK3)/-catenin pathway, collectively reducing glycolytic flux (42)

Under this aspect, aim is to provide at least 120 - 140 meg / litre of plasma over at least 12 hrs, preferably over at least 24 hrs period, more preferably over at least 48 hrs and most preferably over at least 72 hrs