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Firstly, to quantify the glycolytic activity of ILC2s ex-vivo, we analyzed their production of L-lactate, a terminal metabolite produced in the glycolysis pathway, noting that melatonin treatment precipitated a marked decrease in concentration ( Figure 5G )

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(ii) a rise in the levels of putrescine, a derivative metabolite from arginine (urea cycle), and the chemokine CCL2 leading to M2 macrophages differentiation and the impairment of antitumor immunity

Studies have also shown that disulfiram-copper (DSF-Cu) can inhibit aldehyde dehydrogenase (ALDH), targeting cancer stem cells, and therefore has a synergistic effect on the chemoresistance of tumor stem cells that affect sorafenib treatment outcomes (199)

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