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260 LCFAs, particularly -3 PUFAs, have been extensively investigated in cancer cachexia, presumably because of their potential immunomodulatory and redox-regulatory capacities

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Specifically, levels of docosahexaenoic acid (DHA)the most abundant PUFA in the central nervous systemare significantly reduced in the hippocampus and cortex of AD patients ( 4.5 Energetic deficits and synaptic failure Synaptic disruption is a primary pathogenic hallmark of Alzheimer's disease, appearing long before widespread neurodegeneration

doi: 10.15252/embj.201592903 48 KotaniMDetheuxMVandenbogaerdeACommniDVanderwindenJMLe PoulEet al

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