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Their blood pressure was lower, the waist circumference decreased, and their insulin sensitivity improved

Sequential Group Trial to Determine Gastrointestinal Site of Absorption and Systemic Exposure of Azathioprine

After mice or rats were administered 1,2-dibromoethane by gavage at 37-107 mg/kg body weight per day (TWA) for 49-90 weeks or mice were administered 103-117 mg/kg body weight per day in drinking-water for 15-17 months, non-carcinogenic changes such as liver degeneration, testicular atrophy, and forestomach acanthosis and hyperkeratosis in addition to mortality were observed