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40 Interestingly, superoxide dismutase and catalase are increased in older humans, suggesting a compensatory response to oxidative stress

Later, the necroptotic cell death takes over, bringing about more pathological features than apoptosis (222)

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Crucially, the researchers noted that the S-A-GSH molecule was rapidly deacetylated once inside the body, proving that the acetyl shield successfully protected the compound through the digestive tract and then efficiently released the intact, active glutathione directly into the intracellular environment where it is needed to combat oxidative stress

Systemic therapies Research priorities: XIIIXIV Adjuvant systemic treatment Research priorities: XV After curative-intent resection, relapse rates are high, reaching approximately 70% at 5 years 235,236