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By blocking opioid receptors on the POMC neurons, feedback inhibition is prevented further increasing POMC activity

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doi: 10.1016/j.envpol.2021.118445

Research in Pharmaceuticals (MDPI, 2025) reviews BPC-157's mechanisms across tissue injury and repair models, documenting its effects via VEGFR2-Akt-eNOS angiogenic pathways, nitric oxide signaling, and growth hormone receptor expression upregulation in tendon fibroblasts