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Every controlled human GHK-Cu study is topical

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It was effectively applied either immediately (prophylactically) after paracetamol challenge or (therapeutically) administered after a 3 h period had elapsed (note, the maximum depletion of hepatic glutathione occurred 3 h after acute paracetamol dosing (37))

Modulated expression of 4,000+ human genes in cultured fibroblasts Upregulated antioxidant genes including SOD and glutathione peroxidase Downregulated pro-inflammatory and tissue-destructive gene networks Regenerative and protective actions of the GHK-Cu peptide in the light of the new gene data2014Gene Expression Analysis using the Broad Institute Connectivity Map reveals GHK-Cus gene expression signature overlaps with tissue-remodeling, anti-cancer, and neuroprotective pathways, extending its potential research applications