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[Choline deficiency studies - see full reference list] 73-75

The DC maturation process results in upregulation of major histocompatibility complexes (MHC), costimulatory molecules (CD86, CD80, CD40, ICOSL) trafficking receptors (CCR7) and secretion of proinflammatory cytokines 3

[4, 7, 13] Nutrient malabsorption, glutathione and selenium depletion, and reduction of total thiol (cysteine) levels have all been observed to be associated with the pathology of free radical overload that leads to the cellular apoptosis of T lymphocytes