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Other studies have demonstrated the expression of growth hormone receptor at both the mRNA and protein levels and have shown that BPC 157 regulates the phosphorylation of extracellular-signal-regulated kinases 1 and 2 (ERK1/2) as well as their downstream targets, including c-Fos, c-Jun, and Egr-1, key molecules involved in cell growth, migration, and angiogenesis[11,25-29]

While necessary for acute survival, this response generates an enormous quantity of reactive oxygen species (ROS) as collateral damage