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Kernicterus mechanism: When unconjugated bilirubin exceeds albumin-binding capacity (high bilirubin levels, low albumin, acidosis, or displacing drugs), free bilirubin crosses the BBB and deposits in the basal ganglia (globus pallidus, subthalamic nucleus), cerebellum, and hippocampus, causing oxidative damage and neuronal death

Daytime sedation, impaired alertness, mood changes, allergic reactions, injection-site problems, and unexpected reactions all deserve caution

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But call 911 if your symptoms feel life threatening, or if you think youre having a medical emergency

71.3% achieved mRS2 or baseline at 3 months with IVT vs