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and [4] with a follow-up period of 2 months or more after the treatment since this treatment period was stipulated by previous animal studies (11)

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This can result from chronic oxidative stress, heavy metal toxicity (especially iron overload), persistent infections, nutrient insufficiencies (sulfur amino acids, glycine, glutamate, selenium, B-vitamins), liver dysfunction, metabolic stress, and genetic polymorphisms in key enzymes like glutamate-cysteine ligase (GCL) or glutathione S-transferases (GSTs)

Note that none of these identified kinases was shown to phosphorylate RBOHD residue S22, although a previous phosphoproteomic study showed that this residue was phosphorylated in planta 41

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