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10.1038/nrm2122 Nat

Oxidative and Endoplasmic Reticulum Stress in Non-Alcoholic Steatohepatitis Another of the genetic variants associated strongly with NASH, the I148M variant of patatin-like phospholipase domain-containing protein 3 (PNPLA3) appears to disrupt release of mono-unsaturated fatty acids (MUFAs), which activate peroxisome proliferator-activated receptor gamma coactivator 1- (PGC1) and nuclear factor erythroid 2-related factor 2 (NRF2)

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However, efforts to apply organoids in areas such as drug screening and clinical transplantation have been hindered by limitations of the culture conditions, which typically include xenogeneic, chemically undefined or non-standardized components

[32] Glutathione is required for efficient defense against plant pathogens such as Pseudomonas syringae and Phytophthora brassicae