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This also significantly elevated pro-inflammatory factors IL-6, TNF-, and IL-1 in the cerebrospinal fluid, and upregulated lipoxygenase (LOX), PTGS2, IL-6, and TNF- expression in microglial cells, which further promote inflammatory activation

Int Immunopharmacol Deficiency of the innate immune protein IFITM3 impairs phagocytosis and promotes autism-like behaviors in mice

Blood, 2013

Due to the diverse nature of the pathology, especially when it involves unintentional overdosing, it becomes difficult to manage or treat complications linked with DILI