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The terms therapeutically effective (or efficacious) amount and similar descriptions such as an amount efficacious for treatment are intended to mean that amount of a pharmaceutical drug that will alleviate the symptoms of the disorder, condition or disease being treated (i.e., disorder, condition or disease associated with DGAT2 activity) in an animal or human

Results: INT-787 markedly reduced ( P 7 kPa (n = 16 pts) mean LSM values significantly decreased during follow-up (16 18.6 at T0, 10 11.6 at T6, 6 7.1 kPa at T12, p 0.05 for all)

Rescue of mutant CBS activity has been documented by chemical chaperones 34,41 , haem arginate 42 , and proteostasis inhibitors 43 , suggesting a small molecule therapy could be developed 44,45

Given this nutritional profile, developing durian pulp extract as a dietary supplement offers a promising opportunity to meet the recommended daily intake of GSH and -EC, while also leveraging its other potential health benefits

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