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A3: Yes

Benz, C

10.1038/s41556-024-01523-7 71

10.1523/JNEUROSCI.5036-14.2015 J

The second-order rate constant for the reaction of GRX with GSSG is ~10 5 M 1 s 1 , with kinetics for GRX-mediated glu- tathionylation of its active site and subsequent transfer to proteinaceous thiols increasing with increasing GSSG availability [ 66 , 67 ]