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3.1.1 Novel Levodopa Formulations and Delivery 3.1.1.1 Extended-Release Levodopa Efforts to increase levodopas half-life and thereby reduce motor fluctuations and prolong ON-time have started more than 5 decades ago with the introduction of sustained and controlled-release (CR) levodopa formulations [15,16,17], however the evidence base for the efficacy of the first-generation agents has remained slim [14]

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10.2337/db20-0188 63 TianS.MeiJ.ZhangL.WangS.YuanY.LiJ.et al (2024)

Pearson AS, Fang B, Hunt KK, Yu R, Wilson-Heiner M, McDonnell TJ, Sarkiss M, Bruckheimer E, Roth JA, Swisher SG

Physical conditioning: Poor conditioning and lack of fitness can lead to muscle fatigue, increasing the likelihood of muscle spasms