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Description

Thus, when drugs are applied topically, their local bioavailability is reduced, as expected

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Fray et al., 1998

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Cells import cystine from the blood, reconvert it to cysteine (likely using ascorbate as cofactor), and from it synthesize GSH

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ROS subsequently modifies and interferes with proteins, lipids, and DNA, which can induce cell death

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After adding 800 L of cold MeOH/H2O to the frozen tissue, a pellet pestle (Sigma-Aldrich, UK) was used to homogenize the tissue for 1 min

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