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Chromatin immunoprecipitation (ChIP-qPCR) ChIP was performed as previously described (Torres-Garcia et al, 2020b)

doi: 10.3390/cancers13112749

FXR agonism and antagonism have both proven to be beneficial in the mitigation of NASH, leading to much controversy in the field, particularly regarding FXR signaling in the gut

The 4E-BPs are small (~1520 kDa) proteins that interact with eukaryotic translation initiation factor 4E (eIF4E) inhibiting translation initiation, this being a very important regulation point in protein translation

Women with high cytoplasmic levels of IGF-1R in epithelial cells found in benign terminal duct lobular units (TDLUs) biopsies, have up to 15 times increased BrCa incidence [72]