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Results depicted dysregulation of 71 miRNAs in which the majority were already reported to be involved in BC development, suggesting non-subtype specific miRNA involvement in TNBC development

and our own bioinformatic work, which has identified multiple CSDs which undergo redox reactions with the CXXC motif of Trx-like enzymes, suggest that CSDs are cognate substrates of Trx-like enzymes (Haworth and Wouters, 2013)

A., Zakharevich, I., & Gerona, R

As one of the rate-limiting substrates for the synthesis of GSH, which maintains redox balance, Cys availability and GSH levels jointly influence ROS stress and the extent of inflammatory signal amplification, thereby indirectly shaping the pro-inflammatory or reparative functional spectrum ( 2 S), which, as a gaseous signaling molecule, can regulate multiple inflammation-related pathways and affect macrophage phenotypes (7477)

A., Valls, A