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In addition to lowering blood lipids, it can improve renal lesions and reduce proteinuria caused by hyperglycemia[169]

5.2 Antioxidants OS plays a central role in EDC by inducing mitochondrial dysfunction, promoting the release of pro-inflammatory cytokines, and altering synaptic plasticity, thereby exacerbating seizures and worsening depressive symptoms (Becker et al., 2019)

Therefore, introducing drug development technologies, such as computer-aided drug design, high-throughput screening, systems modeling and simulation to obtain derivatives of AS-IV with increased bioavailability and conducting targeted validation or further adopting biocompatible drug carriers, such as nanoparticles, liposomes and micelles encapsulating AS-IV, may be required to achieve its efficient delivery

Dermatopathology (a subspecialty of pathology and dermatology) Dermatopathologists interpret skin biopsies and correlate clinical information with histology