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Whether it is able to selectively remove senescent chondrocytes created by the in vitro expansion requires additional study

Sarbaziha notes that levels peak in young adulthood before declining, and she outlines how the compound modulates gene expression tied to repair processes in addition to exerting acute effects on oxidative stress

Cell Commun

After reaching 70% confluence, fibroblasts were cultured for 24 h in 1% FBS DMEM and then incubated with either TGF1 10ng/ml (Peprotech, Dollard des Ormeaux, Quebec, Canada), GHK 10 nM (Sigma, Markham, Ontario, Canada) or control media (1% FBS DMEM, penicillin, streptavidin) for a further 48 h

For perspective, that level of efficacy means someone weighing 220 pounds could expect to lose approximately 53 pounds over 48 weeks