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Connexin 43 in astrocytes contributes to motor neuron toxicity in amyotrophic lateral sclerosis

The addition of the competitive inhibitor S -methyl glutathione (GSMe) significantly decreased the k red app value (Fig

While pre-fibrillar and fibrillar SOD1 aggregates exhibit significant toxicity, this effect is absent in curcumin-treated samples, suggesting its ability to neutralize harmful intermediates (Shi et al., 2023)

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In inner-sphere electron transfer, the metal cofactor is oxidized or reduced by a ligand bound directly to the metal