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Previous attempts within this LaDA category were designed based on the Kalman filter

10.2307/3350122 Summary Keywords Lyme disease, post-treatment Lyme disease, review, clinical presentation, research priorities Citation Rebman AW and Aucott JN (2020) Post-treatment Lyme Disease as a Model for Persistent Symptoms in Lyme Disease

It is also unclear at present whether these mildly raised metabolite levels have clinical consequences

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Yes, in some cases, HER2 status can change as the disease evolves or after treatment, meaning a tumor may later test as HER2-negative or show reduced HER2 expression