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Glutathione depletion induced by c-Myc downregulation triggers apoptosis on treatment with alkylating agents

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Participant numbers were, however, in accordance with the regulatory guidelines for these types of studies [12,13,14,15]

39 Similar to T-box transcription factor, the role of eomesodermin (Eomes) in chronic infection is controversial, as some researchers found that Eomes expression was upregulated in exhausted CD8 + T cells during chronic infection, 100, 101 whereas others consider that Eomes might compensate for the lack of T-bet in HBV and HCV infection