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This converging evidence suggests that the timing and composition of the early diet are critical environmental determinants

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Oxidative glutamate toxicity in HT22 cells involves the inhibition of the glutamate/cystine antiporter, a subsequent depletion of glutathione, an increase in ROS production, a consecutive impairment of mitochondria, and an influx of Ca 2+ , which ultimately leads to neuronal cell death 25,26,27,31

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