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This may be achieved by creating isogenic corrected cell line grafts from FRDA patient iPSCs

136 This variant is common in African Americans and rare in Whites and Hispanic/Latino people

Metabolic implications downstream of IL-10 Via the IL-10 receptor, IL-10 inhibits glucose uptake by inhibiting SLC2A1/GLUT-1 translocation and instead promotes mitochondrial OXPHOS [124]

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Taken together, our results suggest that alveolar macrophages are major effectors of innate immunity by modulating inflammatory responses towards a Th2 phenotype by producing IL-13, as seen in the adaptive immune response (Fig